The endoplasmic reticulum (ER) uses various mechanisms to ensure that only properly folded proteins enter the secretory pathway. For proteins that oligomerize in the ER, the proper tertiary and quaternary structures must be achieved before their release. Although some proteins fold before oligomerization, others initiate oligomerization cotranslationally. Here, we discuss these different strategies and some of the unique problems they present for the ER quality control system. One mechanism used by the ER is thiol retention. Thiol retention operates by monitoring (...) the redox state of specific cysteine residue(s) and was discovered in studies on the assembly of IgM, a complex oligomeric glycoprotein. This system is also involved in retaining other unassembled proteins in the ER. Mutations that result in uneven numbers of cysteine residues can subject yet other proteins to thiol retention, altering their oligomerization status and function. The implications of these results on the effects of thiol retention on protein function and cell fate are discussed. BioEssays 20:546–554, 1998. © 1998 John Wiley & Sons Inc. (shrink)

The study reports on the results of an empirical investigation of the education and recruitment processes used in HIV vaccine trials conducted in South Africa. Interviews were conducted with 21 key informants involved in HIV vaccine research in South Africa and three focus groups of community advisory board members. Data analysis identified seven major themes on the relationship between education and recruitment: the process of recruitment, the combined dual role of educators and recruiters, conflicts perceived by field staff, pressure to (...) achieve recruitment targets, problems in achieving comprehension, accountability and education as capacity building. The results raise ethical concerns about the adequacy of current informed consent processes in these settings. The study findings bear directly on current debates about issues of exploitation and the scope of moral responsibilities of researchers and funding agencies to assure that HIV clinical prevention research is conducted ethically. (shrink)

Reasoning about concurrent programs involves representing the information that concurrent processes manipulate disjoint portions of memory. In sophisticated applications, the division of memory between processes is not static. Through operations, processes can exchange the implied ownership of memory cells. In addition, processes can also share ownership of cells in a controlled fashion as long as they perform operations that do not interfere, e.g., they can concurrently read shared cells. Thus the traditional paradigm of distributed computing based on locations is replaced (...) by a paradigm of concurrent computing which is more tightly based on program structure. Concurrent Separation Logic with Permissions, developed by O’Hearn, Bornat et al., is able to represent sophisticated transfer of ownership and permissions between processes. We demonstrate how these ideas can be used to reason about fine-grained concurrent programs which do not employ explicit synchronization operations to control interference but cooperatively manipulate memory cells so that interference is avoided. Reasoning about such programs is challenging and appropriate logical tools are necessary to carry out the reasoning in a reliable fashion. We argue that Concurrent Separation Logic with Permissions provides such tools. We illustrate the logical techniques by presenting the proof of a concurrent garbage collector originally studied by Dijkstra et al., and extended by Lamport to handle multiple user processes. (shrink)

The study of the emergence of pretend play in developmental psychology has generally been restricted to analyses of children’s play with toys and everyday objects. The widely accepted criteria for establishing pretence are the child’s manipulation of object identities, attributes or existence. In this paper we argue that there is another arena for pretending—playful pretend teasing—which arises earlier than pretend play with objects and is therefore potentially relevant for understanding the more general emergence of pretence. We present examples of playful (...) pretend teasing in infancy before and around the end of the first year, involving pretend communicative gestures, mis-labelling and almost non-compliance with prohibitions. We argue that the roots of pretence not only lie earlier in human infancy than generally acknowledged, but also are rooted in playful emotional exchanges in which people recognise and respond to violations of communicative gestures and agreements. (shrink)

On spiritualism through studies in Aurobindo Ghose, 1872-1950, as a way for peace.

Sri Aurobindo: the future -- Sri Aurobindo's contribution to humanity -- Sri Aurobindo's realisations -- Spirit & significance of Indian culture -- Sri Aurobindo's revelations.

In spite of the remarkable progress made in the burgeoning field of social neuroscience, the neural mechanisms that underlie social encounters are only beginning to be studied and could —paradoxically— be seen as representing the ‘dark matter’ of social neuroscience. Recent conceptual and empirical developments consistently indicate the need for investigations, which allow the study of real-time social encounters in a truly interactive manner. This suggestion is based on the premise that social cognition is fundamentally different when we are in (...) interaction with others rather than merely observing them. In this article, we outline the theoretical conception of a second-person approach to other minds and review evidence from neuroimaging, psychophysiological studies and related fields to argue for the development of a second-person neuroscience, which will help neuroscience to really go social; this may also be relevant for our understanding of psychiatric disorders construed as disorders of social cognition. (shrink)

Papers presented at National Seminar on Jainism held in 1998 at Hyderabad?

The question of how multinational enterprises respond to local corporate social responsibility expectations remains salient, also in the context of many African governments’ attempts to define and regulate business responsibilities. What determines whether MNEs respond to such local, state-driven expectations as congruent with their global commitment to CSR? Adopting an institutional logics perspective, we argue that a higher global CSR commitment will lead to higher local responsiveness when regulatory distance is low, but it will lead to lower local responsiveness when (...) regulatory distance is high. We find support for our hypothesis using data on 93 MNEs’ responses to the South African state’s Broad-Based Black Economic Empowerment policy. We thus contribute to the global–local CSR literature and show how MNEs’ local CSR responsiveness will be shaped by not only the local context but also their home country and firm-internal environments. (shrink)

Academic misconduct in all its various forms is a challenge for degree-granting institutions. Whilst text-based plagiarism can be detected using tools such as Turnitin™, Plagscan™ and Urkund™, contract cheating and collusion can be more difficult to detect, and even harder to prove, often falling to no more than a ‘balance of probabilities’ rather than fact. To further complicate the matter, some students will make deliberate attempts to obfuscate cheating behaviours by submitting work in Portable Document Format, in image form, or (...) by inserting hidden glyphs or using alternative character sets which text matching software does not always accurately detect.Educators do not tend to think of academic misconduct in terms of criminality per se, but the tools and techniques used by digital forensics experts in law enforcement can teach us much about how to investigate allegations of academic misconduct. The National Institute of Standards and Technology’s Glossary describes digital forensics as ‘the application of computer science and investigative procedures involving the examination of digital evidence - following proper search authority, chain of custody, validation with mathematics, use of validated tools, repeatability, reporting, and possibly expert testimony.’. These techniques are used in criminal investigations as a means to identify the perpetrator of, or accomplices to, a crime and their associated actions. They are sometimes used in cases relating to intellectual property to establish the legitimate ownership of a variety of objects, both written and graphical, as well as in fraud and forgery. Whilst there have been some research articles and case studies that demonstrate the use of digital forensics techniques to detect academic misconduct as proof of concept, there is no evidence of their actual deployment in an academic setting.This paper will examine some of the tools and techniques that are used in law enforcement and the digital forensics field with a view to determining whether they could be repurposed for use in an academic setting. These include methods widely used to determine if a file has been tampered with that could be repurposed to identify if an image is plagiarised; file extraction techniques for examining meta data, used in criminal cases to determine authorship of documents, and tools such as FTK™ and Autopsy™ which are used to forensically examine single files as well as entire hard drives. The paper will also present a prototype of a bespoke software tool that attempts to repurpose some of these techniques into an automated process for detecting plagiarism and / or contract cheating in Word documents.Finally, this article will discuss whether these tools have a place in an academic setting and whether their use in determining if a student’s work is truly their own is ethical. (shrink)

Microorganisms demonstrate conscious-like intelligent behaviour, and this form of consciousness may have emerged from a quantum mediated mechanism as observed in cytoskeletal structures like the microtubules present in nerve cells whichapparently have the architecture to quantum compute. This paper hypothesises the emergence of proto-consciousness in primitivecytoskeletal systems found in the microbial kingdoms of archaea, bacteria and eukarya. To explain this, we make use of the Subject–Object Model (SOM) of consciousness which evaluates the rise of the degree of consciousness to conscious (...) behaviourin these systems supporting the hypothesis of emergence and propagation of conscious behaviour during the pre-Cambrian partof Earth’s evolutionary history. Consciousness as proto-consciousness or sentience computed via primitive cytoskeletal structures substantiates as a driver for the intelligence observed in the microbial world during this period ranging from single-cellular to collective intelligence as a means to adapt and survive. The growth in complexity of intelligence, cytoskeletal system and adaptive behaviours are key to evolution, and thus supports the progression of the Lamarckian theory of evolution driven by quantum mediated proto-consciousness to consciousness as described in the SOM of consciousness. (shrink)

Joint attention to an external object at the end of the first year is typically believed to herald the infant's discovery of other people's attention. I will argue that mutual attention in the first months of life already involves an awareness of the directednesss of attention. The self is experienced as the first object of this directedness followed by gradually more distal 'objects'. this view explains early infant affective self-consciousness within mutual attention as emotionally meaningful, rather than as bearing only (...) a spurious similarity to that in the second and third years of life. Such engagements precede and must inform, rather than derive from, conceptual representations of self and other, and can be better described as self-other conscious affects. (shrink)

In order to understand how infants come to understand others' intentions we need first to study how intentional engagements occur in early development. Engaging with intentions requires that they are, first of all, potentially available to perception and, second, that they are meaningful to the perceiver. I argue that in typical development it is in the infant's responses to others' infant-directed intentional actions that others' intentions first become meaningful. And that it is through the meaningful joining of intentions that understanding (...) continues to develop. I use three common arenas in the first year to illustrate this claim: infants' anticipatory adjustments to being picked up, infants' emerging compliance to others' directives, and infant teasing. Even by the age of two months infants adjust their postures appropriately, gazing at the adult's face as they approach with arms outstretched to pick them up. From the middle of the first year infants come to recognize the meanings of verbal directives and start to comply with them, being drawn further into the cultural worlds of their families. In the last quarter of the first year infants start to playfully tease and foil others' intentions in a variety of ways, actively redirecting the course of intentional engagements. Others' intentions are thus increasingly available to infants, allowing cooperation, challenge, and further elaboration. Joint intentional actions are best understood as the processes through which intention awareness develops rather than just as the products of such awareness. (shrink)

The entry of an external object or the ‘third element’ into the dyad is generally taken as necessary for evidence of an understanding of others' attention, leading to an equating of the terms joint attention and awareness of attention. This chapter considers meta-theoretical and methodological reasons for psychology's disregard of mutual attention in this context and provides an alternative account of the emergence and development of attention awareness. Through the course of the first year human infants show a range of (...) emotional reactions to mutual attention and an increasingly complex range of attempts to regain it when it is absent or retain it when it is present. Prior to the onset of joint attention involving distal objects, mutual attentional engagements expand from an awareness of the self as an ‘object’ of others' attention to an awareness of the infant's own actions and expressions as ‘objects’. Providing the most direct experience of others' attention, mutual attention not only also reveals an awareness of attention but is the basis upon which further appropriate development of attention awareness can occur. (shrink)

For some thirteen years now, the World Bank (‘the Bank’) has regularly reported the number of people living below an international poverty line, colloquially known as ‘$1/day’.3 Reports for the most recent year, 1998, put this number at 1,175.14 million.4 The Bank’s estimates of severe income poverty — its global extent, geographical distribution, and trend over time — are widely cited in official publications by governments and international organizations and in popular media, often in support of the view that liberalization (...) and globalization have helped to reduce poverty worldwide. For instance, the President of the World Bank recently declared: “Over the past few years, these better policies have contributed to more rapid growth in developing countries’ per capita incomes than at any point since the mid-1970s. And faster growth has meant poverty reduction: the proportion of people worldwide living in absolute poverty has dropped steadily in recent decades, from 29% in 1990 to a record low of 23% in 1998. After increasing steadily over the past two centuries, since 1980 the total number of people living in poverty worldwide has fallen by an estimated 200 million — even as the world’s population grew by 1.6 billion.”. (shrink)

The theory-theory is not supported by evidence in the everyday actions of infants and toddlers whose lives a Theory of Mind is meant radically to transform. This paper reviews some of these challenges to the theory-theory, particularly from communication and deception. We argue that the theory’s disconnection from action is both inevitable and paradoxical. The mind–behaviour dualism upon which it is premised requires a conceptual route to knowing minds and disallows a real test of the theory through the study of (...) action. Taking engagement seriously avoids these problems and requires that both lay people and psychologists be participants rather than observers in order to know, and indeed to create, minds. (shrink)

At the heart of the social intelligence hypothesis is the central role of ‘social living’. But living is messy and psychologists generally seek to avoid this mess in the interests of getting clean data and cleaner logical explanations. The study of deception as intelligent action is a good example of the dangers of such avoidance. We still do not have a full picture of the development of deceptive actions in human infants and toddlers or an explanation of why it emerges. (...) This paper applies Byrne & Whiten’s functional taxonomy of tactical deception to the social behaviour of human infants and toddlers using data from three previous studies. The data include a variety of acts, such as teasing, pretending, distracting and concealing, which are not typically considered in relation to human deception. This functional analysis shows the onset of non-verbal deceptive acts to be surprisingly early. Infants and toddlers seem to be able to communicate false information (about themselves, about shared meanings and about events) as early as true information. It is argued that the development of deception must be a fundamentally social and communicative process and that if we are to understand why deception emerges at all, the scientist needs to get ‘back to the rough ground’ as Wittgenstein called it and explore the messy social lives in which it develops. (shrink)

Owing to its benefits on various cognitive aspects, one’s emotions and wellbeing, meditation has drawn interest from several researchers and common public alike. We have different meditation practices associated with many cultures and traditions across the globe. Current literature suggests significant changes in the neural activity among the different practices of meditation, as each of these practices contributes to distinct physiological and psychological effects. Although this is the case, we want to find out if there is an underlying commonality among (...) all these different practices. So, we ask the following questions related to different practices of meditation, the traditional goal of meditation and its significance - What is the central purpose of meditation? Do traditions define the final goal of all the practices of meditation? Are the purpose and goal of these practices different or is there a common goal to be attained through all these distinct practices? Embracing the traditional perspective, through this paper, we want to emphasize, although these techniques and practices may appear different on the periphery, eventually, they seem to subject one to the same experience at the end; a natural meditative state (discussed in various spiritual traditions as the goal of meditation). In view of future studies on different meditation practices and also those exploring this subjective state, we offer some interesting ideas based on the traditional insights on meditation. In this context, we would also like to make a few comments on the way contemporary researchers view different practices of meditation. (shrink)

Smail's "On Deep History and the Brain" is rightly critical of the functionalist fallacies that have plagued evolutionary theory, sociobiology, and evolutionary psychology. However, his attempt to improve on these efforts relies on functional explanations that themselves oversimplify the lessons of neuroscience. In addition, like explanations in evolutionary psychology, they are highly speculative and cannot be confirmed or disproved by evidence. Neuroscience research is too diverse to yield a single picture of brain functioning. Some recent developments in neuroscience research, however, (...) do suggest that cognitive processing provides a kind of “operating system” that can support a great diversity of cultural material. These developments include evidence of “top-down” processing in motor control, in visual processing, in speech recognition, and in “emotion regulation.” The constraints that such a system may place on cultural learning and transmission are worth investigating. At the same time, historians are well advised to remain wary of the pitfalls of functionalism. (shrink)

The purpose of this paper is to examine the effect of corporate governance practices of small cap companies have had on their financial performances. Previous studies have mainly examined governance practices of larger corporations. This analysis focuses on the governance variables that have been highlighted by the New Zealand Securities Commission governance principles and guidelines and also on the governance variables that are supported in the literature as providing an appropriate structure for the firm in the environment in which it (...) operates. The data for 71 small cap companies listed in New Zealand over a five-year period from 2001 to 2005 was analysed. Pooled data, OLS and 2SLS regression techniques were used and Tobin's Q, ROA and OPINC were used as the dependent variables. The evidence does support the hypothesis that the existence of board independence and audit committee has enhanced firm financial performance, as measured by Tobin's Q. (shrink)

Effective and personalized treatment relies heavily on skin disease categorization. In the stratification of skin disorders, it is crucial to identify the subtypes of illnesses to provide an efficient therapy. To attain this aim, researchers have focused their attention on cluster algorithms for the stratification of skin disorders in recent decades. But, cluster algorithms have real-world drawbacks, including experimental noises, a large number of dimensions, and a poor ability to comprehend. Cluster algorithms, in particular, determine the quality of clusters using (...) a single internal evaluation operation in the majority of cases. A single internal assessment procedure is difficult to design and robust for all datasets, which is a problem. The multi-objective particle swarm obtained high sensitivity in the existing work, but it is not able to anticipate all kinds of classes. An optimized cluster distance parameter for K-means clustering is determined using a hybrid particle swarm and moth flame optimization. Multi-objective is guided by two cluster value indices, including the K-means clustering misclassification rate and neural network classification rate. Hybrid PSO will solve the multi-objective problem to identify the optimal cluster for clustering. On the dermatological dataset from the UCI repository, MATLAB R2020a will be used to evaluate the proposed method. This will be followed by an evaluation of the proposed method’s performance using the cluster evaluation indices. (shrink)

Order flows from consistent laws. Our understanding of our universe is changing, but Reality behind it is unchanged. Einstein's relativity amended Newtonian determinism, and was in turn amended by quantum mechanics. Einstein saw a harmonious advance in knowledge, and said, 'God does not play dice'; but Stephen Hawking later saw a radical departure, and said, 'God is a gambler.' This author, a keen student of philosophy with a moderate background of science, sees in these conflicting conclusions the inevitable distortion when (...) 'the relative' is projected on to 'the Absolute'. Therefore he says, 'Do not worry about God. He is not a visiting player like you and me, but the absolute owner of the casino. When He plays, His left hand picks up what His right hand loses. His status remains unaltered. We had better be looking out for ourselves.' The serious point made is that the Absolute includes and exceeds the time-space-causation frame of relativity, and these parameters cannot cross the border. The limitations must be clearly understood. 'Time' of physics is enought to study kinetic processes but not to locate the creative potential. That requires 'time' of our conscious awareness. But bio-science mistakes consciousness to be a product of brain-cells. In truth, consciousness is the energy, and brain is the equipment through which it manifests. Thus TIME is the Achilles' heel of physics, and MIND is the Achilles' heel of biology. The name of Reality is Total Consciousness. It is eternal. Death was never born, and life never died. (shrink)

Fractals are built from patterns generated from immense complexity within the resonant frequencies that connect and tune the universe. Play of such frequencies would result in the exchange of energy and coupling of informational systems at various levels and scales. The present essay serves as a small ride into life’s association with such phenomenon. At a fundamental level communication happens via process called ‘resonance’, and this in turn manifests at a physical level as self-replicating and self-resonating patterns called ‘fractals.’ This (...) could be the reason why at a physical level every structure carries this fractal imprint nature, making it the cosmic signature. The fractal patterns popping out in the natural world surrounding us could be thought of as frozen energy or resonant life patterns. Thus, we hypothesize life could have emerged or appeared as a ‘fracto-resonant’ phenomenon, resulting from the play of interference between material and non-material aspects. In this regard, we propose frequencies or vibrations to be more fundamental to life and call for scientific studies that aim at understanding the effect of various frequencies and vibrations on life forms and consciousness. (shrink)

Just as religion is impassable to its own dogmatic philosophies and ideas, present day science also acts in the same manner. Embracing its reductionist approach, it loses its sight to the most beautiful and insightful possibilities associated with the cosmos and its fundamental constituents around us. The present paper is a holistic ride into few of life’s beautiful constructs that occur as a playful act of the cosmos, and in part hypothesize that the dynamic biological structures or forms could be (...) thought of as frozen energy patterns. Here, the supposition is that the electromagnetic fields that envelop our ecosystems play a central role in its functioning and evolution acting as a unified network interconnecting life at various scales. Supporting a synergetic and holistic view, the present paper is skeptical about the present school of thought, and to other investigations carried out under the sheath of modern science by raising a few fundamental questions. (shrink)

Taking a psychological and philosophical outlook, we approach making as an embodied and embedded skill via the skilled artisan’s experience of having a corporeal, nonlinguistic dialogue with the material while working with it. We investigate the dynamic relation between maker and material through the lens of pottery as illustrated by wheel throwing, claiming that the experience of dialogue signals an emotional involvement with clay. The examination of Merleau-Ponty’s phenomenology of habit, the skilled intentionality framework, and material engagement theory shows that (...) while these theories explain complementary aspects of skillful engagement with the material world, they do not consider the dialogic dimension. By way of explanation, we submit that the artisan’s emotional engagement with the material world is based in openness and recognition and involves dialogue with the material. Drawing on the intimate relationship between movement and emotion, it promotes an open-ended manner of working and permits experiencing with the material, acting into its inherent possibilities. In conclusion, we suggest that dialogue, whether verbal or nonverbal, constitutes a primary means for making sense of the world at large, animate and inanimate. (shrink)

Imagination is the art of exploring beyond the depths of one’s body. Imagination allows one to peek into the void to realize the true existence of its self and feel the existence of eternity. The experience of imagination is a subjective experience of one’s own consciousness and it is this experience makes the experiencer worthy. Creation and creativity are the end aspects of imagination and unfold the hidden mysteries of the cosmos. This essay is a trip across the cosmic energy (...) that creates the self for experiencing its self - a first-hand experience through the virtuosity of imagination. (shrink)